Non-antibiotic control of bacterial infection
Principal Investigator
Mohammed Arshud Dar, University of Saskatchewan
Year the work was done
2013-2017
Overall objective
- To develop a non-antibiotics based in ovo effective, safe and economical strategy to prevent bacterial infections causing early chick mortalities and yolk sac infection (YSI).
Specific objectives
- Improve innate resistance to diverse pathogens.
- Enhance responsiveness to vaccines.
- Achieve a higher level of production.
Outcomes
- Identification and characterization of Escherichia coli strains responsible for yolk sac infection and early chick mortality.
- Development of an experimental model of YSI/ECM in chickens for use in challenge protection studies.
- Challenge protection studies have shown >90%, 70% and 65% protection with in ovo administration of CpG ODN, Poly I:C and polyphophazene respectively.
Application
- In ovo administration of identified immune stimulants may serve as candidates for the replacement of antibiotics for the prevention of YSI and ECM.
This research applies to
Breeders, Broilers, Layers, Turkeys