Novel bioactives of yeast: enzymatic release, identification and their prebiotic effects

Principal Investigator

Bogdan Slominski, University of Manitoba

Year the work was done


Overall objective

  • Enhance the biological activity of yeast and yeast-derived products and to determine the effect of enzyme-modified yeast bioactives on gastrointestinal tract development, immune system function, their prebiotic effects in modifying the microbiome composition, minimizing pathogenic bacteria colonization (i.e., Salmonella, C. perfringens), and thus improving the growth performance of poultry.

Specific objectives

  • Release of bioactive components using the yeast cell lytic enzymes α-mannanase and β1,3-1,6-glucanase.
  • Isolation, fractionation, and identification of the yeast cell wall hydrolysis products.
  • Studies on the effect of isolated yeast bioactives on Salmonella enteritidis colonization in the GI tract and different organs of laying hens and broiler chickens.
  • Studies on the effect of yeast bioactives on gastrointestinal tract development and gut microbiome composition.
  • Studies on the effect of enzyme-pretreated yeasts, isolated yeast bioactives, or yeast lytic enzyme alone on C. perfringens proliferation in the intestine of broiler chickens.
  • Explore the potential for the yeast lytic enzymes to be used directly as feed additives.

This research applies to

Breeders, Broilers, Layers

This research was supported by Agriculture and Agri-Food Canada, Canadian Poultry Research Council , Manitoba Egg Producers and Canadian Bio-Systems Inc.