Immune response to avian influenza virus

Principal Investigator - Shayan Sharif, University of Guelph
Year the work was done - 2010-2013
Overall objective - To delineate the cellular and molecular mechanisms of chicken immune responses to avian influenza virus, and use these responses to develop vaccines that effectively control replication and transmission of the virus.

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Determining the molecular basis of adaptation of influenza viruses from their natural reservoir to domestic poultry

Principal Investigator - Yohannes Berhane, Canadian Food Inspection Agency
Year the work was done - 2010-2013
Overall objective - To better understand how avian influenza virus has developed the ability to infect domestic poultry.

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Study of the transmission of avian influenza virus

Principal Investigator - Jiewen Guan, Canadian Food Inspection Agency
Year the work was done - 2010-2013
Overall objective - To determine the extent to which airborne transmission can contribute to the spread of avian influenza virus.

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Developing novel vaccines against AIV and exploring efficient delivery systems for these vaccines

Principal Investigator - Éva Nagy, University of Guelph
Year the work was done - 2010-2013
Overall objective - To further develop fowl adenovirus-based vectors and determine their potential to generate replication-competent recombinant vaccines.

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Developing novel vaccines against AIV and exploring efficient delivery systems for these vaccines

Principal Investigator - Suresh Tikko, VIDO-Intervec
Year the work was done - 2010-2013
Overall objective - To develop alternative vaccines for avian influenza.

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Developing novel vaccines against AIV and exploring efficient delivery systems for these vaccines

Principal Investigator - Dele Ogunrami, Canadian Food Inspection Agency
Year the work was done - 2010-2013
Overall objective - To develop DNA-based avian influenza vaccine platform, and assess the safety and efficacy of needle-free delivery methods for adenovirus-, virosome- and DNA-based vaccines.

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Assessment of Clostridium perfringens pili in vaccine development for controlling necrotic enteritis in chickens

Principal Investigator - Joshua Gong, Agriculture and Agri-Food Canada
Year the work was done - 2014-2017
Overall objective - To determine if pilin subunits are effective at protecting antigens to control necrotic enteritis in poultry.

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Development of novel and rational vaccine formulations against avian influenza virus infection in chickens

Principal Investigator - Shayan Sharif, University of Guelph
Year the work was done - 2014-2017
Overall objective - To investigate ways to enhance prophylactic strategies against avian influenza virus.

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Assessment and mitigation of contamination risks: critical knowledge to reduce diseases and increase biosecurity compliance

Principal Investigator - Jean-Pierre Vaillancourt, University of Montreal
Year the work was done - 2014-2017
Overall objective - Determine the level of contamination after biosecurity breaches at barn entrances and evaluation of sanitation procedures to mitigate them and determine how pathogen loads are affected by current barn sanitation procedures recommended by the poultry industry.

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Assessment of FadV-9 based vectored vaccine expressing NetB antigen in protection against necrotic enteritis in chickens

Principal Investigator - Éva Nagy, University of Guelph
Year the work was done - 2018-2020
Overall objective - Analyze fowl adenovirus 9 based recombinants containing the NetB gene of Campylobacter perfringens (in vitro studies) and evaluate the recombinants by immunization and challenge studies of chickens (in vivo studies).

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Innovations in antimicrobial alternatives and stewardship in poultry production

Principal Investigator - Shayan Sharif, University of Guelph; Doug Korver, University of Alberta; Juan Carlos Rodriguez-Lecompte, University of Prince Edward Island; Joshua Gong, Agriculture and Agri-Food Canada
Year the work was done - 2018-2023
Overall objective - Design, construct and develop a feasible and effective necrotic enteritis (NE) vaccine strategy in chickens.

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Optimizing antibiotics free preventative strategy using vaccines and probiotics for controlling necrotic enteritis in chickens

Principal Investigator - Susantha Gomis, University of Saskatchewan
Year the work was done - 2018-2023
Overall objective - Develop a strategy for controlling necrotic enteritis in chickens using novel vaccines and probiotics formulated in our lab while comparing and combining them with an autogenous vaccine (will be prepared by VECCI-VET Inc.) and commercially available probiotics (PoultryStar®) options available in Canada.

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A comparative and subtractive reverse vaccinology approach to develop an in ovo vaccine against Clostridium perfringens

Principal Investigator - Martine Boulianne, University of Montreal; Joshua Gong, Agriculture and Agri-Food Canada
Year the work was done - 2018-2023
Overall objective - The main objective is to develop an efficacious vaccine. But given the paucity of current knowledge in the area of C. perfringens and NE pathogenesis and control, the research will yield fundamental new knowledge in these areas.

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Mitigation of intestinal inflammation for poultry and production health

Principal Investigator - Doug Inglis, Agriculture and Agri-Food Canada
Year the work was done - 2018-2023
Overall objective - The research intends to select, formulate, and deliver anti-inflammatory bioactive molecules in vitro and in vivo in an effort to reduce enteric inflammation in chickens and increase productivity in the absence of antibiotic growth promoters.

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Perinatal feeding of epidermal growth factor to enhance development and maintenance of a functional intestinal tract for improved growth and efficacy in poultry

Principal Investigator - Elijah Kiarie, University of Guelph
Year the work was done - 2018-2022
Overall objective - Evaluate the ability of epidermal growth factor (EGF) to stimulate gastrointestinal development of broilers pre-hatch and its subsequent effects of growth performance, gastrointestinal development, resiliency to enteric pathogen challenge and nutrient utilization in the context of an antibiotic-free feeding program.

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Assessment of impact of Canadian infectious bronchitis virus (IBV) variants on egg production and fertility in chickens

Principal Investigator - Mohamed Faizal Abdul Careem, University of Calgary
Year the work was done - 2018-2023
Overall objective - Quantify the impact of IBV variants on egg production and propose mitigation strategies for the variants the impact layer flocks in Canada.

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