Developing novel vaccines against AIV and exploring efficient delivery systems for these vaccines


Principal Investigator

Éva Nagy, University of Guelph

Year the work was done

2010-2013

Overall objective

  • To further develop fowl adenovirus-based vectors and determine their potential to generate replication-competent recombinant vaccines.

Outcomes

  • Dr. Nagy’s group has developed a number of FAdV-based vectors carrying various antigens specific to AIV and other viruses. Preliminary studies have shown that fowl adenovirus can be successfully administered in ovo at 18 days of incubation and that the resulting chicks develop good antibody (Ab) and innate immune responses.
  • The researchers have also shown that orally administered virus induces good Ab response in chickens, and is not shed in the feces. Innate immune response to the vector virus has been characterized. Work is underway to develop an ELISA-based DIVA protocol to test serum from vaccinated chickens.

Application

  • This research is part of an overall program to better understand the biology of avian influenza with the long-term goal of developing rational control strategies in domestic poultry.
  • Dr. Nagy’s FAdV vector may serve as a platform for a new generation of AIV vaccines.

This research applies to

Breeders, Broilers, Hatcheries, Layers, Turkeys

This research was supported by Agriculture and Agri-Food Canada.