Development of novel and rational vaccine formulations against avian influenza virus infection in chickens
Principal Investigator
Shayan Sharif, University of Guelph
Year the work was done
2014-2017
Overall objective
- To investigate ways to enhance prophylactic strategies against avian influenza virus.
Outcomes
- Pathogen associated molecular patterns (PAMPs) were evaluated and three PAMPs with the ability to enhance and immune capabilities were identified and used as adjuvants for an inactivated AI vaccine.
- Vaccine formulations that included PAMP and different administration routes for the vaccine were developed.
- An adenovirus vector for administration of the vaccine was identified, further developed, and used for AI vaccination.
Application
- A virus vector that can be used for delivery avian influenza virus as well as potentially other avian viruses was developed. This vector has been licensed and is being commercialized.
- Several combinations vaccine adjuvants in chickens have been identified and have the potential for commercialization.
This research applies to
Breeders, Broilers, Layers, Turkeys