Innovations in antimicrobial alternatives and stewardship in poultry production

Principal Investigator

Shayan Sharif, University of Guelph; Doug Korver, University of Alberta; Juan Carlos Rodriguez-Lecompte, University of Prince Edward Island; Joshua Gong, Agriculture and Agri-Food Canada

Year the work was done


Overall objective

  • Design, construct and develop a feasible and effective necrotic enteritis (NE) vaccine strategy in chickens.

Specific objectives

  • Development of C. perfringens culture supernatant-based oral vaccine against NE.
  • Design and development of a probiotic-adjuvanted oral vaccine against NE.
  • Construction and development of a recombinant probiotic vectored vaccine expressing C. perfringens protective proteins for prevention of NE.
  • Farm level evaluation of safety and efficacy profiles of vaccine formulations.

This research applies to

Breeders, Broilers, Hatcheries, Layers

This research was supported by Agriculture and Agri-Food Canada, Canadian Poultry Research Council, Ontario Ministry of Agriculture, Food and Rural Affairs, George Weston Seeding Food Innovation, Alberta Agriculture Funding Consortium, Lallemand Inc and Compute Canada.