Mitigation of intestinal inflammation for poultry and production health

Principal Investigator

Doug Inglis, Agriculture and Agri-Food Canada

Year the work was done

2018-2023

Overall objective

  • The research intends to select, formulate, and deliver anti-inflammatory bioactive molecules in vitro and in vivo in an effort to reduce enteric inflammation in chickens and increase productivity in the absence of antibiotic growth promoters.

Specific objectives

  • Adapt novel enteric formulation and delivery strategies to effectively deliver BaMs to the ceca and colon of chickens.
  • Isolate and characterize diverse non-pathogenic autochthonous bacteria (i.e. intestinal residents) from inflamed intestine that have a propensity to colonize inflamed tissue.
  • Utilize autochthonous bacteria to ameliorate chronic and acute inflammation.
  • Engineer select autochthonous bacteria to secrete BaMs (i.e. anti-inflammatory agents) at the site of inflammation.

This research applies to

Breeders, Broilers, Layers, Turkeys

This research was supported by Agriculture and Agri-Food Canada, and Alberta Chicken Producers.