Mitigation of intestinal inflammation for poultry and production health
Principal Investigator
Doug Inglis, Agriculture and Agri-Food Canada
Year the work was done
2018-2023
Overall objective
- The research intends to select, formulate, and deliver anti-inflammatory bioactive molecules in vitro and in vivo in an effort to reduce enteric inflammation in chickens and increase productivity in the absence of antibiotic growth promoters.
Specific objectives
- Adapt novel enteric formulation and delivery strategies to effectively deliver BaMs to the ceca and colon of chickens.
- Isolate and characterize diverse non-pathogenic autochthonous bacteria (i.e. intestinal residents) from inflamed intestine that have a propensity to colonize inflamed tissue.
- Utilize autochthonous bacteria to ameliorate chronic and acute inflammation.
- Engineer select autochthonous bacteria to secrete BaMs (i.e. anti-inflammatory agents) at the site of inflammation.
This research applies to
Breeders, Broilers, Layers, Turkeys